Biosynthetic Strategies for Macrocyclic Peptides

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Macrocyclic Antimicrobial Peptides Engineered from ω-Conotoxin

The potent calcium channel blocker ω-conotoxin MVIIA is a linear cystine-knot peptide with multiple basic amino acids at both termini. This work shows that macrocyclization of MVIIA linking two positive-charge terminal clusters as a contiguous segment converts a conotoxin into an antimicrobial peptide. In addition, conversion of disulfide bonds to amino butyric acids improved the antimicrobial ...

متن کامل

1 Bioactive Macrocyclic Peptides and Peptide Mimics

The number of both naturally occurring and synthesized biologically active cyclic peptides, modified peptides, and peptide mimics is rapidly increasing. So far, many of these sometimes biologically very potent peptides have unfortunately unknown molecular targets or mechanisms of action. This certainly opens up very interesting and challenging research areas with respect to uncovering these tar...

متن کامل

Ribosomal Synthesis of Macrocyclic Peptides for Chronic Myelogenous Leukaemia Treatment

Introduction In Nature, the vast majority of polypeptides are synthesized through translation of the messenger RNA (mRNA) by the joint action of the ribosome and the transfer RNA (tRNA). The mRNA is a transcribed copy of the gene that carries genetic information in the form of series of three-nucleotide sequences referred as ‘codon’. Each codon corresponds to a specific amino acid or a terminat...

متن کامل

Cell penetrating and transytosing peptides: powerful strategies for oral insulin delivery

 Insulin is essential for type 1 and advanced type 2 diabetes to maintain blood glucose levels and increase the patient’s longevity. Frequent subcutaneous insulin injections are usually associated with pain, local tissue necrosis, infection and nerve damage. Recently, a number of new delivery methods such as oral insulin delivery have been developed to overcome these limitations and increase pa...

متن کامل

Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides.

Non-ribosomally synthesized peptides have compelling biological activities ranging from antimicrobial to immunosuppressive and from cytostatic to antitumor. The broad spectrum of applications in modern medicine is reflected in the great structural diversity of these natural products. They contain unique building blocks, such as d-amino acids, fatty acids, sugar moieties, and heterocyclic elemen...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Molecules

سال: 2021

ISSN: 1420-3049

DOI: 10.3390/molecules26113338